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2-methylthioadenosine

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Products Intro: Product Name:2-Methylthioadenosine
CAS:4105-39-9
Purity:97% Package:5g;10;15;1kg
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CAS:4105-39-9
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CAS:4105-39-9
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Products Intro: Product Name:2-Methylthioadenosine
CAS:4105-39-9
Purity:97% Package:mgs,gs,kgs

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2-methylthioadenosine Basic information
Product Name:2-methylthioadenosine
Synonyms:2-Methylthioadenosine ( 2-MeS-Ado );2-[6-AMINO-2-(METHYLSULFANYL)PURIN-9-YL]-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL;(2R,3R,4S,5R)-2-(6-Amino-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;2-Methylthioadenosine ADA inhibitor,platelet ADP receptor (made from GL101374);Zeatin Impurity 1;Adenosine, 2-(methylthio)-;Zeatin Impurity
CAS:4105-39-9
MF:C11H15N5O4S
MW:313.33
EINECS:
Product Categories:
Mol File:4105-39-9.mol
2-methylthioadenosine Structure
2-methylthioadenosine Chemical Properties
Melting point 225 °C
Boiling point 747.6±70.0 °C(Predicted)
density 1.98±0.1 g/cm3(Predicted)
form Solid
pka13.08±0.70(Predicted)
color White to off-white
InChIInChI=1S/C11H15N5O4S/c1-21-11-14-8(12)5-9(15-11)16(3-13-5)10-7(19)6(18)4(2-17)20-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7-,10-/m1/s1
InChIKeyAJNDEAZTAFKOOO-KQYNXXCUSA-N
SMILESOC[C@H]1O[C@@H](N2C3C(=C(N=C(SC)N=3)N)N=C2)[C@H](O)[C@@H]1O
Safety Information
MSDS Information
2-methylthioadenosine Usage And Synthesis
Chemical PropertiesWhite to Off-white Crystalline Powder
Uses2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Definition2-Methylthioadenosine is an adenosine precursor to 2-MeS-ATP, 2-MeS-ADP and 2-MeS-AMP.
References[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
2-methylthioadenosine Preparation Products And Raw materials
Tag:2-methylthioadenosine(4105-39-9) Related Product Information
CANGRELOR 2-METHYLTHIOADENOSINE TRIPHOSPHATE TETRASODIUM 2-METHYLTHIOADENOSINE 5-MONOPHOSPHATE 2-METHYLTHIOADENOSINE, [8-3H]- 2-methylthioadenosine 2-(METHYLTHIO)-ADENOSINE 5'-TRIHYDROGEN DIPHOSPHATE TRISODIUM