1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1)

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1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) manufacturers
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Basic information
Product Name:1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1)
Synonyms:1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1);As-358 hydrochloride
CAS:2374723-26-7
MF:C18H32ClNO2
MW:329.91
EINECS:
Product Categories:
Mol File:2374723-26-7.mol
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Structure
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Chemical Properties
Safety Information
MSDS Information
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Usage And Synthesis
UsesAs-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].
in vivo

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1].

Animal Model:ICR mice[1]
Dosage:1.08, 0.44, 0.27, and 0.14 g/kg
Administration:IG; single (observed for 7 days)
Result:Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
IC 50EBOV; MARV
References[1] Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726. DOI:10.1016/j.ejmech.2020.112726
1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1) Preparation Products And Raw materials
Tag:1-Piperidinepropanoic acid, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, hydrochloride (1:1)(2374723-26-7) Related Product Information
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