L 699333 manufacturers
- L 699333
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- $2120.00
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2026-04-20
- CAS:155238-60-1
- Purity:
- Supply Ability: 10g
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| | L 699333 Basic information |
| Product Name: | L 699333 | | Synonyms: | L 699333;Butanoic acid, 2-[2-[(4S)-1-[(4-chlorophenyl)methyl]-4,5-dihydro-4-methyl-6-[(5-phenyl-2-pyridinyl)methoxy]-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]-, (2R)-rel-;L 699;L699;L-699 | | CAS: | 155238-60-1 | | MF: | C36H35ClN2O4S | | MW: | 627.19 | | EINECS: | | | Product Categories: | | | Mol File: | 155238-60-1.mol |  |
| | L 699333 Chemical Properties |
| | L 699333 Usage And Synthesis |
| Description | L 699333 is a 5-lipoxygenase inhibitor. | | Uses | L-699333 is a 5-lipoxygenase (5-LO) inhibitor belonging to the thieno[2,3,4-cd]indole class. This compound has a 2-ethoxybutyric acid side chain and is a potent inhibitor of the biosynthesis of 5-HPETE and LTB4 produced from human 5-LO, with ICm values of 22 nM, 7 nM, and 3.8 pM for human neutrophils and whole blood, respectively. L-699333 has shown anti-inflammatory and antiasthmatic effects in a variety of animal models, including rat pleurisy models, antigen-induced wheezing models, and awake macaque and sheep asthma models. Its inhibition of 5-LO is highly selective, with higher ICm values or stronger competitive inhibition in FLAP binding assays compared to inhibition of human 15-LO, porcine 12-LO, and ram epididymal cyclooxygenase. The racemic enantiomer 14g of L-699333 is the most potent enantiomer to date, with inhibitory effects similar to those of the known MK-0591, which has been shown in clinical trials to inhibit the biochemical effects of LTB4 biosynthesis in vitro and LTE4 excretion in urine. |
| | L 699333 Preparation Products And Raw materials |
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