|
|
| | 4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide Basic information |
| | 4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide Chemical Properties |
| density | 1.682±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 9.22±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide Usage And Synthesis |
| Uses | GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1]. | | IC 50 | yeast Cdk1: 20 nM (IC50); yeast Pho85: 400 nM (IC50); human CDK2: 1.9 nM (IC50); human CDK9: 10 nM (IC50); human CDK1: 30 nM (IC50); human CDK4: 300 nM (IC50); VEGFR2: 120 nM (IC50); SRC: 930 nM (IC50) | | References | [1] Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13(4):399-407. DOI:10.1016/j.chembiol.2006.02.004 |
| | 4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide Preparation Products And Raw materials |
|