Ro 5-3335 manufacturers
- Ro5-3335
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- $42.00 / 1mg
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2025-05-06
- CAS:30195-30-3
- Min. Order:
- Purity: 99.95%
- Supply Ability: 10g
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| | Ro 5-3335 Basic information |
| Product Name: | Ro 5-3335 | | Synonyms: | Ro 5-3335;7-Chloro-2-oxo-5-(1H-pyrrol-2-yl)-2,3-dihydro-1H-1,4-benzodiazepine;NSC-66020;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;CBFβ-Runx1 inhibitor II;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-5-(1H-pyrrol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one | | CAS: | 30195-30-3 | | MF: | C13H10ClN3O | | MW: | 259.69 | | EINECS: | | | Product Categories: | | | Mol File: | 30195-30-3.mol |  |
| | Ro 5-3335 Chemical Properties |
| Melting point | 256 °C(dec.) | | solubility | Soluble to 100 mM in DMSO | | form | powder to crystal | | color | White to Light red to Green |
| | Ro 5-3335 Usage And Synthesis |
| Uses | Ro 5-3335 is a benzodiazepine is a core binding factor (CBF) leukemia inhibitor. | | Definition | ChEBI: A 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivati
n. | | in vivo | Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models[1].
Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish[1].
Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model[1].
| Animal Model: | C57BL/6 mice (leukemic model)[1] | | Dosage: | 300 mg/kg | | Administration: | Oral administration; daily; for 30 days | | Result: | Reduced the number of c-kit+ cells in the transplanted mice and leukemic cell infiltration in the livers, bone marrow and spleen. |
| | storage | Store at +4°C |
| | Ro 5-3335 Preparation Products And Raw materials |
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