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| | Antitumor?agent-109 Basic information |
| | Antitumor?agent-109 Chemical Properties |
| form | Solid | | color | White to off-white |
| | Antitumor?agent-109 Usage And Synthesis |
| Uses | Antitumor agent-109 (compound 6) is an inhibitor of hyaluronic acid (HY-B0633A) targeting to CD44, as well as an anti-tumor agent. Hyaluronic acid interacts with differentiation cluster 44 (CD44) and is involved in tumor growth and invasion. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM[1]. | | References | [1] Espejo-Román JM, et al. N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect. Eur J Med Chem. 2023 Oct 5;258:115570. DOI:10.1016/j.ejmech.2023.115570 |
| | Antitumor?agent-109 Preparation Products And Raw materials |
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