BDM88855

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BDM88855 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
BDM88855 Basic information
Product Name:BDM88855
Synonyms:BDM88855;Quinoline, 3-chloro-2-(1-piperazinyl)-
CAS:2892824-25-6
MF:C13H14ClN3
MW:247.72
EINECS:
Product Categories:
Mol File:2892824-25-6.mol
BDM88855 Structure
BDM88855 Chemical Properties
Boiling point 414.131±40.00 °C(Press: 760.00 Torr)(predicted)
density 1.257±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka8.309±0.10(predicted)
Safety Information
MSDS Information
BDM88855 Usage And Synthesis
UsesBDM88855 is an allosteric inhibitor for the homolog AcrB protein. BDM88855 can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin (HY-B0925A), Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli[1][2].
References[1] Plé C, et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun. 2022 Jan 10;13(1):115. DOI:10.1038/s41467-021-27726-2
[2] Bera A, et al. Exploring transmembrane allostery in the MexB: DB08385 variant as a promising inhibitor-like candidate against Pseudomonas aeruginosa antibiotic resistance: a computational study. Phys DOI:10.1039/d4cp01620c
BDM88855 Preparation Products And Raw materials
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