8-bromoadenosine 5'-triphosphate

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8-bromoadenosine 5'-triphosphate Basic information
Product Name:8-bromoadenosine 5'-triphosphate
Synonyms:8-bromoadenosine 5'-triphosphate;Adenosine 5'-(tetrahydrogen triphosphate), 8-bromo-
CAS:23567-97-7
MF:C10H15BrN5O13P3
MW:586.08
EINECS:
Product Categories:
Mol File:23567-97-7.mol
8-bromoadenosine 5'-triphosphate Structure
8-bromoadenosine 5'-triphosphate Chemical Properties
Boiling point 983.1±75.0 °C(Predicted)
density 2.85±0.1 g/cm3(Predicted)
pka0.97±0.50(Predicted)
Safety Information
MSDS Information
8-bromoadenosine 5'-triphosphate Usage And Synthesis
Uses8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].
References[1] Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).
[2] P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94. PMID:2970458
[3] Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14. DOI:10.3109/08982104.2011.565476
8-bromoadenosine 5'-triphosphate Preparation Products And Raw materials
Tag:8-bromoadenosine 5'-triphosphate(23567-97-7) Related Product Information
8-Bromoadenosine Adenosine 5′-(tetrahydrogen triphosphate), P′′→5′-ester with adenosine, sodium salt (1:3) NA Rp-8-bromo-Cyclic AMPS (sodium salt) 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE LITHIUM SALT Adenosine 5'-(trihydrogen diphosphate), P'→5-ester with β-D-ribofuranose