HYOCHOLIC ACID manufacturers
- Hyocholic acid
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- $44.00 / 1mg
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2025-09-04
- CAS:547-75-1
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
- HYOCHOLIC ACID
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- $0.00 / 1KG
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2025-04-04
- CAS:547-75-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
- HYOCHOLIC ACID
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- $1.00 / 1Kg
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2021-12-10
- CAS:547-75-1
- Min. Order: 1KG
- Purity: 99.99%
- Supply Ability: 500 Metric Ton/Day
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| | HYOCHOLIC ACID Basic information |
| Product Name: | HYOCHOLIC ACID | | Synonyms: | LAMBDA-MURICHOLIC ACID;HYOCHOLIC ACID;GAMMA MURICHOLIC;3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)-cholan-24-oicaci;3-ALPHA,6-ALPHA,7-ALPHA-TRIHYDROXY-5-BETA-CHOLAN-24-OIC ACID;3A,6A-7A-TRIHYDROXY-5B-CHOLAN-24-OIC ACID;5B-CHOLAN-24-OIC ACID-3A,6A,7A-TRIOL;5-BETA-CHOLAN-24-OIC ACID-3-ALPHA,6-ALPHA,7-ALPHA-TRIOL | | CAS: | 547-75-1 | | MF: | C24H40O5 | | MW: | 408.57 | | EINECS: | 208-935-8 | | Product Categories: | | | Mol File: | 547-75-1.mol |  |
| | HYOCHOLIC ACID Chemical Properties |
| Melting point | 162 °C | | Boiling point | 565.7±40.0 °C(Predicted) | | density | 1.184±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Ethanol (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 4.76±0.10(Predicted) | | color | Light Brown to Brown | | Optical Rotation | +5.525 |
| | HYOCHOLIC ACID Usage And Synthesis |
| Uses | 3α,6α,7α-Trihydroxy-5β-cholanic Acid is one of the bile acids categorizes under muricholic acid, a group of bile acids found in human urine due to its additional hydroxyl groups. The synthesis of 3α,6α,7α-Trihydroxy-5β-cholanic Acid was shown to be promoted due to overexpression of cholesterol 7α-hydroxylase enzyme. | | Definition | ChEBI: A trihydroxy-5beta-cholanic acid in which the three hydroxy substituents are located at the 3alpha-, 6alpha- and 7alpha-positions. | | Biological Activity | Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis. | | in vivo | Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3].
Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3].
| Animal Model: | BA depletion pigs[3] | | Dosage: | 20 mg/kg | | Administration: | Oral administration (p.o.) | | Result: | Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. |
| Animal Model: | db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] | | Dosage: | 100 mg/kg/day | | Administration: | Oral administration (p.o.) | | Result: | Improved oral glucose tolerances shown by lower glucose levels.
Increased circulating active GLP-1 levels and fasting insulin levels.
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| | HYOCHOLIC ACID Preparation Products And Raw materials |
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