PROTAC HPK1 Degrader-1

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PROTAC HPK1 Degrader-1 Basic information
Product Name:PROTAC HPK1 Degrader-1
Synonyms:PROTAC HPK1 Degrader-1;1H-Isoindole-1,3(2H)-dione, 4-[[2-[3-[4-[4-[3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CAS:3034182-97-0
MF:C43H43N7O8
MW:785.85
EINECS:
Product Categories:PROTACs-Please select
Mol File:3034182-97-0.mol
PROTAC HPK1 Degrader-1 Structure
PROTAC HPK1 Degrader-1 Chemical Properties
density 1.378±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.74±0.40(predicted)
Safety Information
MSDS Information
PROTAC HPK1 Degrader-1 Usage And Synthesis
UsesPROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].
References[1] Zeng S, et al. Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling. Bioorg Chem. 2024 Feb;143:107016. DOI:10.1016/j.bioorg.2023.107016
PROTAC HPK1 Degrader-1 Preparation Products And Raw materials
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