RyR2 stabilizer-1

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RyR2 stabilizer-1 Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
RyR2 stabilizer-1 Basic information
Product Name:RyR2 stabilizer-1
Synonyms:RyR2 stabilizer-1
CAS:3012675-16-7
MF:C28H46N2O3S
MW:490.74
EINECS:
Product Categories:
Mol File:3012675-16-7.mol
RyR2 stabilizer-1 Structure
RyR2 stabilizer-1 Chemical Properties
Boiling point 629.3±55.0 °C(predicted)
density 1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka15.00±0.20(predicted)
Safety Information
MSDS Information
RyR2 stabilizer-1 Usage And Synthesis
UsesRyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias[1].
References[1] Gyuzel Y. Mitronova, et al. 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2aStimulating Activities. Journal of Medicinal Chemistry. 2023， Article ASAP. DOI:10.1021/acs.jmedchem.3c01235
RyR2 stabilizer-1 Preparation Products And Raw materials
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