ALPHA-AMANITIN manufacturers
- ALPHA-AMANITIN
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2026-03-31
- CAS:23109-05-9
- Min. Order:
- Purity: 0.99
- Supply Ability:
- alpha-Amanitin
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- $9.00 / 10g
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2024-04-17
- CAS:23109-05-9
- Min. Order: 10g
- Purity: 99%
- Supply Ability: 10 tons
- α-Amanitin
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- $60.00 / 50mg
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2024-01-08
- CAS:23109-05-9
- Min. Order: 1mg
- Purity: 99.96%
- Supply Ability: 1kg
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| | ALPHA-AMANITIN Basic information |
| | ALPHA-AMANITIN Chemical Properties |
| Melting point | 254-255 °C(lit.) | | alpha | D20 +191° | | Boiling point | 1622.2±65.0 °C(Predicted) | | density | 1.1626 (rough estimate) | | refractive index | 1.7400 (estimate) | | storage temp. | −20°C | | solubility | H2O: 1.0 mg/mL | | pka | 9.63±0.70(Predicted) | | form | powder | | color | white to light yellow | | Optical Rotation | +19120 (H2O) | | biological source | Amanita phalloides | | Water Solubility | Soluble to 5 mM in ethanol and to 5 mM in water | | ε(extinction coefficient) | 13,500 at 310nm in H2O at 1M | | Merck | 13,370 | | BRN | 1071138 | | InChIKey | CIORWBWIBBPXCG-PWKRRBCNNA-N | | SMILES | CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2 |
| Hazard Codes | T+ | | Risk Statements | 26/27/28-33-26/28 | | Safety Statements | 36/37/39-45-36/37-28 | | RIDADR | UN 3462 6.1/PG 2 | | WGK Germany | 3 | | RTECS | BD6195000 | | F | 8-10-18-21 | | HazardClass | 6.1(a) | | PackingGroup | I | | HS Code | 2934999090 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 1 Oral
STOT RE 2 | | Hazardous Substances Data | 23109-05-9(Hazardous Substances Data) | | Toxicity | LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland) |
| | ALPHA-AMANITIN Usage And Synthesis |
| Uses | α-Amanitin has been used:
- for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
- to induce nephrotoxicity in mice renal tissues
- to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay
| | Biological Activity | α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure. | | Biochem/physiol Actions | The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis. | | in vivo | The intravenous LD50 dose of alpha-Amanitin is 0.327 mg/kg body weight after intravenous injection into BALB/c mice. After 12 h of alpha-Amanitin injection in caudal vein, the levels of WBC, RBC and HGB decrease significantly, while those of BUN and Crea increase significantly in serum. alpha-Amanitin inhibits some genes (Hsp90b1, Irx4, etc.), whose encoded proteins regulate the RNA polymerase II activity. alpha-Amanitin down-regulates some proteins (Nmi, Trpc5, etc.) taking part in the transcription progress[1]. alpha-Amanitin has potent activity in DTC suppression. Mice injected with alpha-Amanitin (0.4 mg/kg, i.p.)-treated cells maintain their body weight, while those receiving a peritoneal injection of MKN45 cells show a constant decrease in body weight[2]. | | IC 50 | Traditional Cytotoxic Agents | | storage | Store at -20°C |
| | ALPHA-AMANITIN Preparation Products And Raw materials |
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