2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE

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Company Name:	TopScience Biochemical
Tel:	00852-68527855
Email:	info@itopbiochem.com
Products Intro:	Product Name:2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE Purity:99.9% Package:1g;USD\|50g;USD

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:GW-406381 CAS:221148-46-5 Purity:98.00% Package:1 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel:	+86-057181025280; +8617767106207
Email:	sales@molcore.com
Products Intro:	Product Name:GW-406381 CAS:221148-46-5 Purity:NLT 98% Remarks:MC541794

Company Name:	Aladdin Scientific
Tel:
Email:	tp@aladdinsci.com
Products Intro:	Product Name:GW-406381 CAS:221148-46-5 Purity:99% Package:$85.9/1mg;$240.9/5mg;Bulk package Remarks:99%

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:GW-406381 CAS:221148-46-5 Package:100mg;1140USD\|50mg;754USD

2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE manufacturers

2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE Basic information

Product Name:	2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE
Synonyms:	2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE;GW 406381;GW 406381 - GW 406381X;Pyrazolo[1,5-b]pyridazine, 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-;GW 406381,GW406381;2-(4-Ethoxyphenyl)-3-(4-(methylsulfonyl)phenyl)pyrazolo[1,5-b]pyridazine
CAS:	221148-46-5
MF:	C21H19N3O3S
MW:	393.46
EINECS:
Product Categories:
Mol File:	221148-46-5.mol

2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE Chemical Properties

density	1.30±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO, sonicated:25.0(Max Conc. mg/mL);63.0(Max Conc. mM)
form	A solid
pka	0.65±0.30(Predicted)
color	White to yellow

Safety Information

MSDS Information

2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE Usage And Synthesis

Uses	GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2].
IC 50	COX-2
References	[1] Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87. DOI:10.1016/j.pain.2006.08.032 [2] Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259. PMID:19099009

2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE Preparation Products And Raw materials

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