盐酸奈替康唑
| 中文名称 | 盐酸奈替康唑 |
|---|---|
| 中文同义词 | 盐酸奈替康唑;盐酸奈康唑;盐酸萘康唑;(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐;NETICONAZOLE盐酸盐 |
| 英文名称 | Neticonazole Hydrochloride |
| 英文同义词 | 1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride;Atolant;Neticonazole hydrochloride;SS-717;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride;long-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride |
| CAS号 | 130773-02-3 |
| 分子式 | C17H23ClN2OS |
| 分子量 | 338.9 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 130773-02-3.mol |
| 结构式 |  |
盐酸奈替康唑 性质
| 熔点 | 145-147° |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/ml（737.68 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Fungal
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.
Western Blot Analysis
| Cell Line: | C4-2B cells |
| Concentration: | 10 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. |
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
| Animal Model: | Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells |
| Dosage: | 1 ng/kg, 10 ng/kg and 100 ng/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Significantly improved the survival of IDB mice with CRC xenograft tumors. |
628-17-1
![(E)-1-[2-甲巯基-1-[2-羟基苯基]乙烯基]-1H-咪唑](/CAS/20180629/GIF/138206-46-9.gif)
138206-46-9
130773-02-3
以1-碘戊烷和(E)-1-[2-甲巯基-1-[2-羟基苯基]乙烯基]-1H-咪唑为原料，合成(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐的一般步骤如下：将式（4）化合物(E)-1-[1-(2-羟基苯基)-2-(甲硫基)乙烯基]-1H-咪唑（15.1 g，65 mmol）、氢氧化钾（5.1 g，91 mmol）和1-碘戊烷（15.55 g，78 mmol）溶于75 mL DMF中，室温搅拌反应3.5小时。反应完成后，将反应液倒入375 mL水中，用乙酸乙酯萃取，有机相依次用水和饱和食盐水洗涤。减压浓缩有机相，得到油状物。将该油状物溶于氯化氢气体饱和的乙酸乙酯中，搅拌10小时。反应液中析出白色固体，经过滤，用乙腈洗涤，真空干燥，得到16.4 g白色固体产物。产率：73.2%。HPLC纯度（面积归一化法）：99.61%，单一杂质含量<0.1%。
参考文献：
[1] Patent: CN107556245, 2018, A. Location in patent: Paragraph 0045; 0046
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-128365 | 盐酸奈替康唑 Neticonazole hydrochloride | 130773-02-3 | 25mg | 650元 |
| 2025/12/22 | HY-128365 | 盐酸奈替康唑 Neticonazole hydrochloride | 130773-02-3 | 10 mM * 1 mLin DMSO | 715元 |