- Koumine
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- $53.00
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2026-07-15
- CAS:1358-76-5
- Purity: 99.69%
- Supply Ability: 10g
- Koumine
-
-
2023-02-24
- CAS:1358-76-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- koumine
-
- $15.00
-
2021-07-02
- CAS:1358-76-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
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| | koumine Basic information |
| Product Name: | koumine | | Synonyms: | koumine;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole;Koumine-RM;Koumine, 10 mM in DMSO;Koumine (Standard) | | CAS: | 1358-76-5 | | MF: | C20H22N2O | | MW: | 306.4 | | EINECS: | | | Product Categories: | Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 1358-76-5.mol |  |
| | koumine Chemical Properties |
| Melting point | 168℃ | | Boiling point | 436.5±45.0 °C(Predicted) | | density | 1.42 | | storage temp. | 2-8°C | | solubility | DMSO : 31.25 mg/mL (101.99 mM; Need ultrasonic) | | form | powder | | pka | 8.67±0.40(Predicted) | | color | Yellow-brown | | Optical Rotation | [α]/D 295 to 245° | | InChI | InChI=1/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/s3 | | InChIKey | VTLYEMHGPMGUOT-KWZROIJWNA-N | | SMILES | C1C=CC2N=C3[C@]4([H])OC[C@@]5([H])[C@]([H])([C@]6(C=C)CN(C)[C@]5(C[C@@]36C=2C=1)[H])C4 |&1:6,10,12,14,20,22,r| |
| WGK Germany | WGK 3 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 2 Oral |
| | koumine Usage And Synthesis |
| Description | The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth.,
is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It
has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C
(dec.) and a hydrobromide, m.p. 269°C (dec.). | | Chemical Properties | Soluble in acetone, chloroform, ether, benzene and other organic solvents, insoluble in water. Sourced from Gelsemium elegans (Gardn. et Champ.) Benth. | | Occurrence | Koumine is an alkaloid isolated from Gelsemium elegans Benth. | | Uses | Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages. | | in vivo | Koumine is less toxic, with the median lethal dose (LD50) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA)[2].
Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg[2].
Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level[3]. | | References | Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938) |
| | koumine Preparation Products And Raw materials |
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