PROTAC PIN1 degrader-1

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PROTAC PIN1 degrader-1 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PROTAC PIN1 degrader-1 Basic information
Product Name:PROTAC PIN1 degrader-1
Synonyms:PROTAC PIN1 degrader-1
CAS:3038591-59-9
MF:C51H52N10O7
MW:917.02
EINECS:
Product Categories:
Mol File:3038591-59-9.mol
PROTAC PIN1 degrader-1 Structure
PROTAC PIN1 degrader-1 Chemical Properties
density 1.42±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka10.70±0.40(predicted)
Safety Information
MSDS Information
PROTAC PIN1 degrader-1 Usage And Synthesis
UsesPROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part)[1].
References[1] Liu C, et al. Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J Med Chem. 2024 Sep 12;67(17):15780-15795. DOI:10.1021/acs.jmedchem.4c01412
PROTAC PIN1 degrader-1 Preparation Products And Raw materials
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