| Company Name: |
Alfa Chemistry |
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+1-5166625404; |
| Email: |
Info@alfa-chemistry.com |
| Company Name: |
ChemOrigin Pharm |
| Tel: |
15026428026 19002516454 |
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ChemOrigin@126.com |
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| | HuR degrader 2 Basic information |
| Product Name: | HuR degrader 2 | | Synonyms: | HuR degrader 2;2,6-Piperidinedione, 3-[6-(1H-pyrrolo[2,3-b]pyridin-4-yl)-3-benzofuranyl]-;Degron's HuR degrader (Compound 3) | | CAS: | 3040301-46-7 | | MF: | C20H15N3O3 | | MW: | 345.35 | | EINECS: | | | Product Categories: | | | Mol File: | 3040301-46-7.mol |  |
| | HuR degrader 2 Chemical Properties |
| density | 1.395±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 11.16±0.40(predicted) | | form | Solid | | color | Off-white to light yellow |
| | HuR degrader 2 Usage And Synthesis |
| Uses | HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02[1]. | | References | [1] Zou L, et al., Compounds for modulating hur (elavl1). WO2024114639. |
| | HuR degrader 2 Preparation Products And Raw materials |
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