1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester manufacturers
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| | 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Basic information |
| | 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Chemical Properties |
| Boiling point | 338.5±22.0 °C(Predicted) | | density | 2.083±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 10.03±0.50(Predicted) | | Appearance | White to off-white Solid |
| | 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Usage And Synthesis |
| Synthesis | Methyl 1H-pyrazole-3-carboxylate (0.5 g, 4.3 mmol, 1.1 eq.) and N-iodosuccinimide (NIS) (0.97 g, 3.9 mmol, 1 eq.) were dissolved in acetonitrile (15 mL), and trifluoroacetic acid (0.1 mL) was added as a catalyst. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The concentrated residue was partitioned between ethyl acetate (EtOAc) and 5% aqueous sodium bicarbonate (NaHCO3). The organic layer was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Finally, the residue was purified by silica gel column chromatography to afford the target product methyl 4-iodo-1H-pyrazole-3-carboxylate (0.61 g, 61% yield). | | References | [1] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 159 - 166
[2] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00315
[3] Russian Chemical Bulletin, 2010, vol. 59, # 8, p. 1549 - 1555 |
| | 1H-Pyrazole-3-carboxylic acid, 4-iodo-, methyl ester Preparation Products And Raw materials |
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