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| | E-Cadherin Rabbit Monoclonal Antibody (Clone RM244) Basic information |
| | E-Cadherin Rabbit Monoclonal Antibody (Clone RM244) Chemical Properties |
| | E-Cadherin Rabbit Monoclonal Antibody (Clone RM244) Usage And Synthesis |
| Description | E-cadherin is a calcium-dependent adhesion molecule that mediates the formation of adherens junctions and regulates epithelial cell integrity and tissue formation.1,2 It is a transmembrane glycoprotein composed of an extracellular cadherin domain that mediates cell-cell interactions, a transmembrane domain, and a cytoplasmic domain that interacts with a variety of adaptor proteins, including β-catenin, to influence cytoskeletal dynamics.3,4 E-cadherin is expressed by epithelial cells and localizes to the cell surface, where it assembles into cis-cadherin dimers that subsequently form trans-cadherin dimers with cadherins expressed on adjacent cells, resulting in cell-cell adhesion.5 E-cadherin cell surface expression is regulated by clathrin-dependent or -independent endocytosis and drives cytoskeletal rearrangements that are necessary for wound closure.6 Loss of E-cadherin is a key feature of the epithelial-to-mesenchymal transition (EMT), a process that promotes tumorigenesis and cancer metastasis.1 Cayman’s E-Cadherin Rabbit Monoclonal Antibody (Clone RM244) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes E-cadherin at approximately 120 kDa from human samples.WARNING This product is not for human or veterinary use. |
| | E-Cadherin Rabbit Monoclonal Antibody (Clone RM244) Preparation Products And Raw materials |
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