| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:"2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)"
Purity:95%
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)
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| | 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) Basic information |
| | 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) Chemical Properties |
| solubility | Water: Soluble |
| | 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) Usage And Synthesis |
| Description | 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (2’-deoxy-3’-MANT-GTP) is a fluorescent derivative of dGTP (Item No. 35771).1,2,3 It selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 260, 1,200, 420, and 470 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 220 nM), and B. anthracis edema factor AC toxin (Ki = 630 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 43 and 14 µM, respectively).1 2’-deoxy-3’-MANT-GTP has been used to study the activity of various GTPases, including elongation factor Tu (EF-Tu) and H-Ras p21.2,3 A related derivative, 2'(3')-MANT-GTP (Item No. 38469), displays an emission maximum of 442 nm upon excitation at 350 nm.4WARNING This product is not for human or veterinary use. | | References | [1] ANDREAS GILLE. Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.[J]. The Journal of Biological Chemistry, 2004, 279 19: 19955-19969. DOI: 10.1074/jbc.m312560200
[2] M V RODNINA. Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.[J]. EMBO Journal, 1995, 14 11: 2613-2619. DOI: 10.1002/j.1460-2075.1995.tb07259.x
[3] JACOB JOHN. Kinetics of interaction of nucleotides with nucleotide-free H-ras p21[J]. Biochemistry Biochemistry, 1990, 29 25: 6058-6065. DOI: 10.1021/bi00477a025
[4] HIRATSUKA T. New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes[J]. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1983, 742 3: Pages 496-508. DOI: 10.1016/0167-4838(83)90267-4 |
| | 2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) Preparation Products And Raw materials |
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