Lipid U 105

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Lipid U 105 Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Lipid U 105 Basic information
Product Name:Lipid U 105
Synonyms:Lipid U 105
CAS:3049129-14-5
MF:C53H106N2O6
MW:867.42
EINECS:
Product Categories:
Mol File:3049129-14-5.mol
Lipid U 105 Structure
Lipid U 105 Chemical Properties
Boiling point 834.091±65.00 °C(Press: 760.00 Torr)(predicted)
density 0.942±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility Methyl Acetate: Soluble: =10 mg/ml
pka14.405±0.10(predicted)
Safety Information
MSDS Information
Lipid U 105 Usage And Synthesis
DescriptionLipid U 105 is an ionizable cationic lipid (pKa = 6.65) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of circular RNA in vitro and in vivo.1 LNPs containing lipid U 105 and encapsulating circular RNA encoding VEGF-A increase the levels of VEGF-A in, and increases the proliferation and migration of, human umbilical vein endothelial cells (HUVECs). Topical administration of the same LNPs increases wound healing in a mouse model of diabetes induced by a high-fat and -sugar diet.WARNING This product is not for human or veterinary use.
References[1] A single dose of VEGF-A circular RNA sustains in situ long-term expression of protein to accelerate diabetic wound healing[J]. Journal of Controlled Release, 2024, 373: Pages 319-335. DOI: 10.1016/j.jconrel.2024.07.018
Lipid U 105 Preparation Products And Raw materials
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