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| | Vimentin Rabbit Monoclonal Antibody (Clone RM289) Basic information |
| | Vimentin Rabbit Monoclonal Antibody (Clone RM289) Chemical Properties |
| | Vimentin Rabbit Monoclonal Antibody (Clone RM289) Usage And Synthesis |
| Description | Vimentin is a cytoskeleton intermediate filament protein.1 It is composed of monomers that each contain a central α-helix rod domain, which facilitates formation of a coiled-coil dimer required for vimentin filament assembly, as well as N-terminal head and C-terminal tail domains.1,2 It is expressed in mesenchymal stem cells and cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.3 Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol.2 It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity.1 Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites.4 It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center.5 Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).6,7 ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.6 Cayman’s Vimentin Rabbit Monoclonal Antibody (Clone RM289) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | Vimentin Rabbit Monoclonal Antibody (Clone RM289) Preparation Products And Raw materials |
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