- 4-CYANO-7-AZAINDOLE
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- $1.10 / 1g
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2025-11-18
- CAS:344327-11-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-CYANO-7-AZAINDOLE
-
- $1.00 / 1KG
-
2019-07-12
- CAS:344327-11-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | 4-CYANO-7-AZAINDOLE Basic information |
| Product Name: | 4-CYANO-7-AZAINDOLE | | Synonyms: | 4-CYANO-7-AZAINDOLE;1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE;4-Cyano-7-azaindole 97%;4-Cyano-1H-pyrrolo[2,3-b]pyridine;7-Azaindole-4-carbonitrile;1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile(9CI);4-CYANO-7-AZAINDOLE ISO 9001：2015 REACH;SWF-42 | | CAS: | 344327-11-3 | | MF: | C8H5N3 | | MW: | 143.15 | | EINECS: | | | Product Categories: | PYRIDINE;Azaindoles | | Mol File: | 344327-11-3.mol |  |
| | 4-CYANO-7-AZAINDOLE Chemical Properties |
| Melting point | 195-197℃ | | density | 1.29 | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.05±0.40(Predicted) | | form | solid | | color | Yellow | | InChI | 1S/C8H5N3/c9-5-6-1-3-10-8-7(6)2-4-11-8/h1-4H,(H,10,11) | | InChIKey | HAROKQXDLYCEQV-UHFFFAOYSA-N | | SMILES | N#Cc1ccnc2[nH]ccc12 |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 4-CYANO-7-AZAINDOLE Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis Reference(s) | The Journal of Organic Chemistry, 71, p. 4021, 2006 DOI: 10.1021/jo0602571 | | Synthesis | Step 1: To degassed N,N-dimethylacetamide (200 mL), 4-chloro-7-azaindole (30.0 g, 196.7 mmol), zinc cyanide (23.1 g, 196.7 mmol), zinc powder (1.28 g, 19.67 mmol), tris(dibenzylideneacetone)dipalladium (3.6 g, 3.93 mmol) and diphenylphosphino ferrocene (4.36 g, 7.86 mmol). The reaction mixture was heated at 120 °C for 18 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into crushed ice (1.5 kg) and the solid product was collected by filtration. The solid product was washed with ethyl acetate (2 x 1500 mL) and filtered after stirring for 0.5 h at a time. The filtrates were combined, concentrated and crystallized from ethyl acetate to give 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (22.0 g, 78% yield).1H NMR (400 MHz, DMSO-d6): δ 12.20 (br s, 1H), 8.41 (d, J = 4.8 Hz, 1H), 7.84 (s, 1H), 7.56 (d, J = 4.8 Hz, 1H), 6.65 (d, J = 1.6 Hz, 1H). | | References | [1] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 64
[2] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 52 |
| | 4-CYANO-7-AZAINDOLE Preparation Products And Raw materials |
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