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| | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Basic information |
| Product Name: | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone | | Synonyms: | Prasugrel Intermediate 4;2-Bromo-2-(2-fluorophenyl);Ethanone, 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-;2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone;Cylopropylcarbonyl-2-flurobenzyl bromide;2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone;Chemical intermediate for Prasugrel;2-broMo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one | | CAS: | 204205-33-4 | | MF: | C11H10BrFO | | MW: | 257.1 | | EINECS: | 812-641-0 | | Product Categories: | | | Mol File: | 204205-33-4.mol |  |
| | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Chemical Properties |
| Boiling point | 293.0±25.0 °C(Predicted) | | density | 1.574±0.06 g/cm3(Predicted) | | Fp | 131° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) | | form | Oil to Low-Melting Solid | | form | Oil to Low-Melting Solid | | color | Yellow to Light Brown | | Optical Rotation | 0.0900°(C=1g/100mL, CHCL3, 20°C, 589nm) | | CAS DataBase Reference | 204205-33-4(CAS DataBase Reference) |
| | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Usage And Synthesis |
| Uses | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone is a reagent used in the synthesis of potent anti-oxidant agents. | | Synthesis | General procedure for the synthesis of 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone from 1-cyclopropyl-2-(2-fluorophenyl)ethanone: 1-cyclopropyl-2-(2-fluorophenyl)ethanone (17.8 g, 100 mmol), iodine monobromide (62 g, 300 mmol), and 1-butyl-3-methylimidazolium bromide (8.7 g, 40 mmol) were dissolved in 150 mL of anhydrous tetrahydrofuran. The reaction was stirred at 40 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of ice water. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with saturated sodium bisulfite solution. The organic phase was concentrated and purified by recrystallization from ethanol to give 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (24.5 g, 95.3% yield, 99.73% purity). | | References | [1] Patent: CN105884793, 2016, A. Location in patent: Paragraph 0033; 0034; 0035
[2] Patent: WO2013/14295, 2013, A1. Location in patent: Page/Page column 19-20
[3] Patent: WO2009/122440, 2009, A1. Location in patent: Page/Page column 31
[4] Patent: CN105884599, 2016, A. Location in patent: Paragraph 0025; 0062-0064
[5] Patent: CN104418718, 2018, B. Location in patent: Paragraph 0040; 0044; 0047; 0048; 0052; 0056 |
| | 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Preparation Products And Raw materials |
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