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| | (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Basic information |
| Product Name: | (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE | | Synonyms: | AKOS 354;L-HOMOSERINE LACTONE HYDROBROMIDE;L-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE;HOMOSERINE LACTONE HBR;(S)-(-)-2-AMINO-4-BUTYROLACTONE HYDROBROMIDE;(S)-2-AMINO-4-BUTYROLACTONE HYDROBROMIDE;(S)-(-)-alpha-Amino-gamma-butyrolactone hydrobromide 99%;L-(-)-ALPHA-AMINO--BUTYROLACTONE HYDROBROMIDE | | CAS: | 15295-77-9 | | MF: | C4H8BrNO2 | | MW: | 182.02 | | EINECS: | 218-571-1 | | Product Categories: | Amino Acids | | Mol File: | 15295-77-9.mol |  |
| | (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Chemical Properties |
| Melting point | 225 °C (dec.)(lit.) | | storage temp. | 2-8°C | | solubility | Methanol (Slightly), Water (Slightly) | | form | Liquid | | color | Clear yellow to brownish, may darken on storage | | Optical Rotation | [α]20/D 21°, c = 1 in H2O | | Sensitive | Hygroscopic | | BRN | 3912375 | | CAS DataBase Reference | 15295-77-9(CAS DataBase Reference) |
| | (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Usage And Synthesis |
| Chemical Properties | WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER | | Uses | L-Homoserine Lactone Hydrobromide is a reactant in the synthesis of tritium labeled and photoactivatable N-acyl-L-homoserine lactones. | | Uses | Used to prepare pseudopeptide inhibitors for Ras farnesyl-protein transferase as well as selenomethionine. | | Synthesis | General procedure for the synthesis of α-amino-gamma-butyrolactone hydrobromide from L-methionine: Bromoacetic acid (46.0 kg), 2-propanol (69.0 kg), and acetic acid (69.0 kg) were sequentially added to an aqueous solution (69 kg) of L-methionine (46 kg) at ambient temperature. The resulting mixture was heated to reflux (85 °C to 95 °C) and stirred continuously at this temperature until the completion of the reaction was confirmed by 1H NMR. After completion of the reaction, the mixture was concentrated under reduced pressure and co-evaporated with 2-propanol. To the concentrated mixture was added 2-propanol (161.0 kg) followed by the slow addition of a 10 wt% HCl/dioxane solution (102 kg) at ambient temperature. The resulting slurry was heated to about 60°C and stirred for about 4 hours. Subsequently, the mixture was cooled to about 22°C and stirring was continued for about 2 hours. Filtration gave the product α-amino-γ-butyrolactone hydrobromide (Ma), which was was washed with two portions of 2-propanol (28 kg each) and dried under vacuum at 40 °C to give a white to off-white solid (39.3 kg, 70% yield).The 1H NMR (D2O) data were as follows: δ 4.79 (s, 2H), 4.61 (dd, 1H), 4.49-4.41 (m. 2H), 2.80 (m, 1H), 2.42 (m, 1H). | | References | [1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 6, p. 938 - 954
[2] Organic and Biomolecular Chemistry, 2005, vol. 3, # 2, p. 253 - 262
[3] Molecules, 2013, vol. 18, # 3, p. 3266 - 3278
[4] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3242 - 3249
[5] Patent: US2010/256366, 2010, A1. Location in patent: Page/Page column 20 |
| | (S)-(-)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROBROMIDE Preparation Products And Raw materials |
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