(+/-)-chloro-APB

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:SKF-82958 hydrobromide；(±)-SKF 82958 hydrobromide;Chloro-APB hydrobromide
CAS:74115-01-8
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:(±)-SKF 82958 HYDROBROMIDE;CHLORO-APB HYDROBROMIDE
CAS:74115-01-8
Purity:95.0% windy 1046
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:SKF 82958
CAS:74115-01-8
Purity:98% Package:5mg Remarks:V4977
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:SKF-82958 hydrobromide
CAS:74115-01-8
Package:2mg;71USD
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Products Intro: Product Name:(+/-)-chloro-APB
CAS:74115-01-8
Purity:99% Package:5mg

(+/-)-chloro-APB manufacturers
(+/-)-chloro-APB Basic information
Product Name:(+/-)-chloro-APB
Synonyms:(+/-)-chloro-APB;1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-, hydrobromide (1:1);6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol hydrobromide;(±)-SKF 82958 HYDROBROMIDE;CHLORO-APB HYDROBROMIDE;SKF 82958 hydrobromide,SKF82958 hydrobromide;(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine HBr;SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide
CAS:74115-01-8
MF:C19H21BrClNO2
MW:410.74
EINECS:
Product Categories:
Mol File:74115-01-8.mol
(+/-)-chloro-APB Structure
(+/-)-chloro-APB Chemical Properties
Melting point 203-204 °C(Solv: isopropanol (67-63-0); ethyl ether (60-29-7))
storage temp. Store at -20°C
solubility DMSO: 100 mM; Water: 5 mM, with warming
form A solid
color White to off-white
Safety Information
MSDS Information
(+/-)-chloro-APB Usage And Synthesis
UsesSKF 82958 Hydrobromide is a dopamine (D1) agonist. Also, it augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices.
HazardA poison.
in vivo

SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate[2].
SKF-82958 hydrobromide (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].

Animal Model:Male Sprague-Dawley rats[3]
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
IC 50D1 Receptor
(+/-)-chloro-APB Preparation Products And Raw materials
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