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- Tadalafil-D3
-
- $179.00
-
2026-05-11
- CAS:960226-55-5
- Purity:
- Supply Ability: 10g
- Tadalafil-D3
-
- $282.00
-
2023-05-27
- CAS:960226-55-5
- Min. Order: 10mg
- Purity: 96%
- Supply Ability: 100
- Tadalafil-D3
-
-
2023-05-27
- CAS:960226-55-5
- Min. Order: 1mg
- Purity: 96%
- Supply Ability: 50 mg
|
| | Tadalafil-d3 Basic information |
| Product Name: | Tadalafil-d3 | | Synonyms: | Tadalafil-d3;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(methyl-d3)-, (6R,12aR)-;PubChem ID: 46782966;[2H3]-Tadalafil;Tadalafil D3Q: What is
Tadalafil D3 Q: What is the CAS Number of
Tadalafil D3 Q: What is the storage condition of
Tadalafil D3 Q: What are the applications of
Tadalafil D3;(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-(2H?)methyl-3,6,17-triazatetracyclo[8.7.0.03,?.011,1?]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione;D3-Tadalafil | | CAS: | 960226-55-5 | | MF: | C22H18N3O4 | | MW: | 388.39602 | | EINECS: | | | Product Categories: | Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Intermediates & Fine Chemicals,Chiral Reagents | | Mol File: | 960226-55-5.mol |  |
| | Tadalafil-d3 Chemical Properties |
| Melting point | 281-283°C | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Unstable in Methanol | | InChI | InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3 | | InChIKey | WOXKDUGGOYFFRN-PDIFIXMTNA-N | | SMILES | c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r| |
| | Tadalafil-d3 Usage And Synthesis |
| Description | Tadalafil-d3 is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. | | Chemical Properties | Tadalafil-d3 is White Solid | | Uses | Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry. | | Uses | Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. | | References | [1] GRAEME L CARD. Structural basis for the activity of drugs that inhibit phosphodiesterases.[J]. Structure, 2004, 12 12: 2233-2247. DOI: 10.1016/j.str.2004.10.004
[2] VANESSA DE FáTIMA LIMA PAIVA MEDEIROS. The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats.[J]. Acta cirurgica brasileira, 2017, 32 2: 90-97. DOI: 10.1590/s0102-865020170201
[3] MICHAEL SEIMETZ. Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.[J]. PLoS ONE, 2015: e0129327. DOI: 10.1371/journal.pone.0129327 |
| | Tadalafil-d3 Preparation Products And Raw materials |
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