| Company Name: |
Hangzhou J&H Chemical Co., Ltd.
|
| Tel: |
0571-87396432 |
| Email: |
sales@jhechem.com |
| Products Intro: |
Product Name:Tomentosin
CAS:33649-15-9
Purity:98% HPLC Package:50KG;10KG;5KG;1KG
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| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:(3aR,7S,8aR)-7-Methyl-3-methylene-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
CAS:33649-15-9
Purity:98% Package:1mg;5mg;10mg Remarks:BD01397895
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Tomentosin
CAS:33649-15-9
Purity:98.20% Package:1mg/RMB 4160
|
Tomentosin manufacturers
- Tomentosin
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- $413.00
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2026-07-27
- CAS:33649-15-9
- Purity: 98.20%
- Supply Ability: 10g
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| | Tomentosin Basic information |
| Product Name: | Tomentosin | | Synonyms: | (3aR)-3,3aα,4,7,8,8aα-Hexahydro-7β-methyl-3-methylene-6-(3-oxobutyl)-2H-cyclohepta[b]furan-2-one;(3aα)-3-Methylene-6-(3-oxobutyl)-7β-methyl-3,3aα,4,7,8,8aα-hexahydro-2H-cyclohepta[b]furan-2-one;Tomentosin;Tomentosin (Parthenium);C09562;2H-Cyclohepta[b]furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxobutyl)-, (3aR,7S,8aR)-;(3aR,7S,8aR)-7-Methyl-3-methylene-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one | | CAS: | 33649-15-9 | | MF: | C15H20O3 | | MW: | 248.32 | | EINECS: | | | Product Categories: | | | Mol File: | 33649-15-9.mol |  |
| | Tomentosin Chemical Properties |
| Melting point | 121-122 °C(Solv: methanol (67-56-1)) | | Boiling point | 416.2±45.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (50 mg/ml) | | form | oil | | color | Yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month. |
| | Tomentosin Usage And Synthesis |
| Description | Extracts of Inula which contain tomentosin (33649-15-9) have been used for centuries in traditional medicine for the treatment of inflammation.1 It suppresses the production of inflammatory mediators in RAW264.7 cells by inhibiting NFkB activation.2 It induces telomere shortening and caspase-dependent apoptosis in cervical cancer cells3 and induces apoptosis in human osteosarcoma MG-63 cells4. It causes G2/M arrest and apoptosis in human melanoma cell lines.5 | | Uses | Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells[1]. | | Definition | ChEBI: Tomentosin is a sesquiterpene lactone. | | References | [1] YUE LU . Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation[J]. Journal of ethnopharmacology, 2012, 143 1: Pages 151-157. DOI:10.1016/j.jep.2012.06.015
[2] HYO-HYUN PARK. Suppressive effect of tomentosin on the production of inflammatory mediators in RAW264.7 cells.[J]. Biological & pharmaceutical bulletin, 2014, 37 7: 1177-1183. DOI:10.1248/bpb.b14-00050
[3] NAWEL MERGHOUB. Tomentosin Induces Telomere Shortening and Caspase-Dependant Apoptosis in Cervical Cancer Cells[J]. Journal of cellular biochemistry, 2016, 118 7: 1689-1698. DOI:10.1002/jcb.25826
[4] CHANG MIN LEE. Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species.[J]. International Journal of Molecular Sciences, 2019, 20 6. DOI:10.3390/ijms20061508
[5] SHARON ROZENBLAT . Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines[J]. Biochemical pharmacology, 2008, 75 2: Pages 369-382. DOI:10.1016/j.bcp.2007.08.024 |
| | Tomentosin Preparation Products And Raw materials |
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