Pyranoridine phosphate manufacturers
- Pyranoridine phosphate
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- $1.00 / 1KG
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2025-12-12
- CAS:76748-86-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200000KG
- Pyranoridine phosphate
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- $1.10 / 1g
-
2025-11-18
- CAS:76748-86-2
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | Pyranoridine phosphate Basic information |
| Product Name: | Pyranoridine phosphate | | Synonyms: | PYRANORIDINE TETRAPHOSPHATE;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno;phosphate(1:4);pyranoridinephosphate;Pyranaridine tetraphosphate;4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4);2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate;4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci | | CAS: | 76748-86-2 | | MF: | C29H35ClN5O6P | | MW: | 616.05 | | EINECS: | | | Product Categories: | Inhibitor | | Mol File: | 76748-86-2.mol |  |
| | Pyranoridine phosphate Chemical Properties |
| Melting point | 233-236° (dec) | | storage temp. | 2-8°C | | solubility | acetic acid: soluble5mg/mL | | form | solid | | color | Light yellow to yellow | | InChIKey | YKUQEKXHQFYULM-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 63-22-41 | | Safety Statements | 26-36/37-39 | | WGK Germany | 2 | | RTECS | SK4920000 | | Toxicity | LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao) |
| | Pyranoridine phosphate Usage And Synthesis |
| Uses | Pyronaridine Phosphate is an antimalarial drug. | | Biological Activity | pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1]. | | in vivo | Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice[2].
| Animal Model: | Echinococcus granulosus-infected mice model[2] | | Dosage: | 57 mg/kg | | Administration: | Oral administration, q.d. for 30 days | | Result: | Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss. |
| | IC 50 | Plasmodium | | references | [1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31. |
| | Pyranoridine phosphate Preparation Products And Raw materials |
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