- piconol
-
- $122.00 / 1KG
-
2025-09-25
- CAS:586-98-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-(Hydroxymethyl)pyridine Basic information |
| | 2-(Hydroxymethyl)pyridine Chemical Properties |
| Melting point | 5 °C | | Boiling point | 112-113 °C/16 mmHg (lit.) | | density | 1.131 g/mL at 25 °C (lit.) | | vapor pressure | 3.47Pa at 25℃ | | refractive index | n20/D 1.543(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | miscible | | form | Liquid | | pka | 13.48±0.10(Predicted) | | color | Clear colorless to yellow or brown | | Specific Gravity | 1.131 | | PH | 6-8 (100g/l, H2O, 20℃) | | Odor | pyridine odor | | Water Solubility | miscible | | Sensitive | Hygroscopic | | BRN | 107849 | | InChIKey | SHNUBALDGXWUJI-UHFFFAOYSA-N | | LogP | 0.11 | | CAS DataBase Reference | 586-98-1(CAS DataBase Reference) | | NIST Chemistry Reference | Piconol(586-98-1) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | UT4689000 | | F | 3-8 | | Hazard Note | Irritant/Keep Cold/Hygroscopic | | HazardClass | IRRITANT, HYGROSCOPIC, KEEP COLD | | HS Code | 29333999 |
| | 2-(Hydroxymethyl)pyridine Usage And Synthesis |
| Chemical Properties | CLEAR COLORLESS TO YELLOW OR BROWN LIQUID | | Uses | decongestant | | Uses | A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells. | | Uses | 2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity. | | Preparation | The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids. 
| | Definition | ChEBI: 2-Pyridinylmethanol is a member of pyridines. |
| | 2-(Hydroxymethyl)pyridine Preparation Products And Raw materials |
|