4-Cholesten-3-one manufacturers
- Cholestenone
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- $58.00 / 500mg
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2026-03-13
- CAS:601-57-0
- Min. Order:
- Purity: 98.41%
- Supply Ability: 10g
- 4-Cholesten-3-one
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- $0.00 / 1G
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2026-02-02
- CAS:601-57-0
- Min. Order: 1G
- Purity: 99%
- Supply Ability: 2000tons
- 4-Cholesten-3-one
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- $0.00 / 1KG
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2025-06-27
- CAS:601-57-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 4-Cholesten-3-one Basic information |
| Product Name: | 4-Cholesten-3-one | | Synonyms: | 17-(1,5-dimethylhexyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecah;17-(1,5-DIMETHYLHEXYL)-10,13-DIMETHYL-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-ONE;4-CHOLESTEN-3-ONE;3-KETO-4-CHOLESTENE;3-OXO-4-CHOLESTENE;CHOLEST-4-ENE-3-ONE;CHOLESTENONE;3-Oxocholest-4-ene | | CAS: | 601-57-0 | | MF: | C27H44O | | MW: | 384.64 | | EINECS: | 210-005-1 | | Product Categories: | Steroids;Steroids (Others);Biochemistry | | Mol File: | 601-57-0.mol |  |
| | 4-Cholesten-3-one Chemical Properties |
| Melting point | 79-82 °C | | alpha | 92.5 º (c=2, CHCl3) | | Boiling point | 451.27°C (rough estimate) | | density | 0.9717 (rough estimate) | | refractive index | 1.5100 (estimate) | | storage temp. | -20°C | | solubility | Chloroform (Sparingly), Methanol (Slightly, Heated) | | form | Solid | | color | White to Off-White | | Optical Rotation | [α]23/D +91.0°, c = 2 in chloroform | | Water Solubility | <0.5 g/L | | BRN | 4707774 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25H,6-16H2,1-5H3/t19-,22+,23-,24+,25+,26+,27-/m1/s1 | | InChIKey | NYOXRYYXRWJDKP-GYKMGIIDSA-N | | SMILES | [H][C@@]12[C@]([C@](CC3)(C)C(CC2)=CC3=O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)C | | CAS DataBase Reference | 601-57-0(CAS DataBase Reference) | | NIST Chemistry Reference | Cholest-4-en-3-one(601-57-0) | | EPA Substance Registry System | Cholest-4-en-3-one (601-57-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-36-26 | | WGK Germany | 3 | | RTECS | FZ7700000 | | TSCA | TSCA listed | | HS Code | 29142900 | | Storage Class | 11 - Combustible Solids |
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(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
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ACROS
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SigmaAldrich
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ALFA
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| | 4-Cholesten-3-one Usage And Synthesis |
| Description | Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells when used at a concentration of 50 μg/ml. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats when administered at doses of 700-1,000 mg/kg per day, inducing hypertrophy in and reducing the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids. | | Chemical Properties | white to light yellow crystals or powder | | Uses | 4-Cholesten-3-one is used as a chiral building block for proteomics research. It is an intestinal metabolite of cholesterol and exhibits an anti-obesity effect on animals. | | Definition | ChEBI: Cholest-4-en-3-one is a cholestanoid that is cholest-4-ene substituted by an oxo group at position 3. It has a role as a human metabolite and a plant metabolite. It is a cholestanoid and a 3-oxo-Delta(4) steroid. | | General Description | Cholestenone is a cholesterol metabolite and analog, which substitutes membrane cholesterol and elevates membrane fluidity. | | References | [1] G SALEN. Inverse relationship between plasma cholestanol concentrations and bile acid synthesis in sitosterolemia.[J]. Journal of Lipid Research, 1994, 35 10: 1878-1887.
[2] CHUN-LIN CHEN. Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells.[J]. Journal of Receptors and Signal Transduction, 2017, 37 2: 189-199. DOI: 10.1080/10799893.2016.1203944
[3] D STEINBERG J A D S FREDRICKSON. Effects of 4-cholestenone in animals and in man.[J]. Proceedings of the Society for Experimental Biology and Medicine, 1958, 97 4: 784-790. DOI: 10.3181/00379727-97-23880
[4] KE WU. Production, Purification, and Identification of Cholest-4-en-3-one Produced by Cholesterol Oxidase from Rhodococcus sp. in Aqueous/Organic Biphasic System.[J]. Biochemistry Insights, 2015, 8 Suppl 1: 1-8. DOI: 10.4137/bci.s21580 |
| | 4-Cholesten-3-one Preparation Products And Raw materials |
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