|
|
| | 1-Chloroethyl ethyl carbonate Basic information |
| | 1-Chloroethyl ethyl carbonate Chemical Properties |
| Melting point | 159-161°C | | Boiling point | 159-161 °C(lit.) | | density | 1.136 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.413 | | Fp | 65°C | | storage temp. | 2-8°C | | solubility | Chloroform | | form | Oil | | color | Colourless | | BRN | 3536477 | | Stability: | Moisture Sensitive | | InChI | 1S/C5H9ClO3/c1-3-8-5(7)9-4(2)6/h4H,3H2,1-2H3 | | InChIKey | YVRGKFXJZCTTRB-UHFFFAOYSA-N | | SMILES | CCOC(=O)OC(C)Cl | | CAS DataBase Reference | 50893-36-2(CAS DataBase Reference) | | EPA Substance Registry System | Carbonic acid, 1-chloroethyl ethyl ester (50893-36-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-28 | | WGK Germany | 3 | | F | 10-21 | | TSCA | TSCA listed | | HS Code | 29209090 | | Storage Class | 10 - Combustible liquids |
| | 1-Chloroethyl ethyl carbonate Usage And Synthesis |
| Chemical Properties | Clear pale yellowish liquid | | Synthesis | 71.5 g (0.5 mmol) of 1-chloroethyl chloroformate, 40 g of ethanol and 52.0 g of triethylamine were sequentially added to 250 mL of toluene solution under cooling at 0°C. After the addition was completed, the reaction system was kept stirred at 0°C for about 2 hours. Subsequently, the reaction system was slowly warmed to room temperature and the reaction was continued for 1 hour. Upon completion of the reaction, the solid impurities were removed by filtration and 78.5 g of the intermediate 1-chloroethyl ethyl carbonate (H-1) was purified by distillation. | | References | [1] Synthesis, 1986, # 8, p. 627 - 632
[2] Patent: EP1437352, 2004, A1. Location in patent: Page 17
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5748 - 5763
[4] Patent: WO2016/207216, 2016, A1. Location in patent: Page/Page column 70
[5] Patent: CN107652239, 2018, A. Location in patent: Paragraph 0098 |
| | 1-Chloroethyl ethyl carbonate Preparation Products And Raw materials |
|