- Pyrazinamine
-
- $29.00 / 1g
-
2025-12-22
- CAS:5049-61-6
- Min. Order:
- Purity: 99.72%
- Supply Ability: 10g
- Pyrazinamine
-
- $29.00 / 1g
-
2025-12-15
- CAS:5049-61-6
- Min. Order:
- Purity: 99.72%
- Supply Ability: 10g
- Aminopyrazine
-
- $0.00 / 25KG
-
2025-12-01
- CAS:5049-61-6
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
|
| | Aminopyrazine Basic information |
| | Aminopyrazine Chemical Properties |
| Melting point | 118-120 °C (lit.) | | Boiling point | 167.6°C (rough estimate) | | density | 1.1031 (rough estimate) | | refractive index | 1.5200 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Methanol | | pka | 3.22±0.10(Predicted) | | form | Crystalline Powder | | color | Slightly yellow to beige | | Water Solubility | soluble | | BRN | 107025 | | InChIKey | XFTQRUTUGRCSGO-UHFFFAOYSA-N | | LogP | -0.070 | | CAS DataBase Reference | 5049-61-6(CAS DataBase Reference) | | NIST Chemistry Reference | Aminopyrazine(5049-61-6) |
| | Aminopyrazine Usage And Synthesis |
| Chemical Properties | SLIGHTLY YELLOW TO BEIGE CRYSTALLINE POWDER | | Uses | 2-Aminopyrazine acts as a raw material in a four-component synthesis of imidazolidines. It is also used as an intermediate in synthetic chemistry. In addition, 2-aminopyrazine can be reacted with α-ketohydroximoyl chlorides to form 3-nitrosoimidazo[1,2-a]pyrazines. | | Application | 2-Aminopyrazine is a synthetic intermediate useful for pharmaceutical synthesis. It is used to synthesize favipiravir and substrate in a four-component synthesis of imidazolidines. | | Definition | ChEBI: Aminopyrazine is a member of pyrazines. | | Synthesis | General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield. | | References | [1] Patent: CN105622526, 2016, A. Location in patent: Paragraph 0020; 0021; 0022
[2] Patent: CN108570011, 2018, A. Location in patent: Paragraph 0012; 0013; 0014 |
| | Aminopyrazine Preparation Products And Raw materials |
|