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| | 2-Amino-3'-hydroxy-acetophenone hydrochloride Basic information |
| Product Name: | 2-Amino-3'-hydroxy-acetophenone hydrochloride | | Synonyms: | 2-AMino-3'-hydroxy-acetophenone HCl;Phenylephrine Impurity 26;2-amino-1-(3-hydroxy-phenyl)-ethanone;2-Amino-1-(3-hydroxyphenyl)ethanone Hydrochloride;2-amino-1-(3-hydroxyphenyl)ethan-1-one hydrochloride;2-Amino-3'-hydroxy-acetophenone hydrochloride | | CAS: | 14665-75-9 | | MF: | C8H9NO2.ClH | | MW: | 187.625 | | EINECS: | | | Product Categories: | | | Mol File: | 14665-75-9.mol |  |
| | 2-Amino-3'-hydroxy-acetophenone hydrochloride Chemical Properties |
| Melting point | 221–222°C | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | Pale Beige to Brown |
| | 2-Amino-3'-hydroxy-acetophenone hydrochloride Usage And Synthesis |
| Uses | 2-Amino-3’-hydroxy-acetophenone Hydrochloride is a reactant in the synthesis of TRPM8 modulators. | | Preparation | Preparation by hydrolysis of m-(benzoyloxy)- a-amino-acetophenone hydrochloride (SM) (m.p. 202–205°) with refluxing 10% hydrochloric acid (quantitative yield), for 2 h (80%); with 37% hydrochloric acid in chlorobenzene at 90° for 3 h (90%). SM was obtained by reaction of hexamethylenetetramine with m-(benzoyloxy)- a-bromoacetophenone (m.p. 162°) in ethanol in the presence of 37% hydrochloric acid for 6 h at r.t. (75%). |
| | 2-Amino-3'-hydroxy-acetophenone hydrochloride Preparation Products And Raw materials |
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