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| | Tyr-α-CGRP (human) Basic information |
| Product Name: | Tyr-α-CGRP (human) | | Synonyms: | Tyr-α-CGRP (human);Tyr-α-CGRP (huMan)
Tyr-CGRP I (huMan);H-Tyr-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2;Tyr-a-CGRP (huMan);Tyr-α-CGRP (human) (trifluoroacetate salt);Tyr-α-CGRP (huMan) Tyr-CGRP I (huMan);α-Calcitonin gene-related peptide (human), N-L-tyrosyl- (9CI);Tyr-alpha-CGRP (human) trifluoroacetate salt | | CAS: | 124756-98-5 | | MF: | C174H277F3N52O53S2 | | MW: | 4066.5029896 | | EINECS: | | | Product Categories: | | | Mol File: | 124756-98-5.mol |  |
| | Tyr-α-CGRP (human) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: 1 mg/ml | | form | A lyophilized powder |
| | Tyr-α-CGRP (human) Usage And Synthesis |
| Description | Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide (α-CGRP; ).1 It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively).2 Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM).1 It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).3 | | References | 1. Poyner, D.R., Andrew, D.P., Brown, D., et al. Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes Br. J. Pharmacol. 105(2),441-447(1992).
2. Hay, D.L., Christopoulos, G., Christopoulos, A., et al. Pharmacological discrimination of calcitonin receptor: Receptor activity-modifying protein complexes Mol. Pharmacol. 67(5),1655-1665(2005).
3. Dennis, T., Fournier, A., St. Pierre, S., et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity J. Pharmacol. Exp. Ther. 251(2),718-725(1989). |
| | Tyr-α-CGRP (human) Preparation Products And Raw materials |
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