- Ferrostatin-1
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- $59.00
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2026-07-17
- CAS:347174-05-4
- Purity: 99.30%
- Supply Ability: 10g
- Ferrostatin-1 (Fer-1)
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- $1.00
-
2019-12-23
- CAS:347174-05-4
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| | Ferrostatin-1 (Fer-1) Basic information |
| Product Name: | Ferrostatin-1 (Fer-1) | | Synonyms: | Ethyl 3-amino-4-(cyclohexylamino)benzoate;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Ferrostatin-1 (Fer-1);Fer 1;FER-1;FER 1;FER1;FERROSTATIN-1;FERROSTATIN 1;FERROSTATIN1;(Ferrostatin-1 (Fer-1))3-Amino-4-cyclohexylamino benzoic acid ethyl ester;3-amino-4-(cycL | | CAS: | 347174-05-4 | | MF: | C15H22N2O2 | | MW: | 262.35 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 347174-05-4.mol |  |
| | Ferrostatin-1 (Fer-1) Chemical Properties |
| Boiling point | 437.3±35.0 °C(Predicted) | | density | 1.150±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 4.78±0.11(Predicted) | | form | powder | | color | purple to brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | InChI | InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3 | | InChIKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N | | SMILES | C(OCC)(=O)C1=CC=C(NC2CCCCC2)C(N)=C1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2922498590 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Ferrostatin-1 (Fer-1) Usage And Synthesis |
| Description | Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4. | | Uses | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis. | | Definition | ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine. | | Biochem/physiol Actions | Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models. | | Synthesis | General procedure for the synthesis of ethyl 3-amino-4-(cyclohexylamino)benzoate from ethyl 4-(cyclohexylamino)-3-nitrobenzoate: the nitro derivative (24.28 g, 83 mmol) was dissolved in methanol (150 mL) and 20% Pd(OH)2/carbon catalyst (200 mg) was added. The hydrogenation reaction was carried out under hydrogen atmosphere at 1 atmosphere for 3 days. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation of the solvent under reduced pressure to afford the target product ethyl 3-amino-4-(cyclohexylamino)benzoate (21.72 g, 100% yield) as a dark purple solid. | | storage | Store at +4°C | | References | [1] SCOTT J DIXON. Ferroptosis: an iron-dependent form of nonapoptotic cell death.[J]. Cell, 2012, 149 5: 1060-1072. DOI:10.1016/j.cell.2012.03.042
[2] CHRISTOPHE LOUANDRE. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib[J]. International Journal of Cancer, 2013, 133 7: 1732-1742. DOI:10.1002/ijc.28159
[3] RACHID SKOUTA. Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models[J]. Journal of the American Chemical Society, 2014, 136 12: 4551-4556. DOI:10.1021/ja411006a
[4] GRAZYNA NOWAK Ruben M Sridharan Soundararajan. Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells.[J]. American Journal of Physiology-renal Physiology, 2013, 305 5: F764-76. DOI:10.1152/ajprenal.00061.2013 |
| | Ferrostatin-1 (Fer-1) Preparation Products And Raw materials |
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