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DL-AP4 sodium salt manufacturers
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| | DL-AP4 sodium salt Basic information |
| Product Name: | DL-AP4 sodium salt | | Synonyms: | DL-AP4 sodium salt;DL-2-Amino-4-phosphonobutyricacidsodiumsalt;DLAP4 Sodium salt,DL AP4 Sodium salt,DL-AP-4 Sodium salt;DL-AP4 sodium salt (mM/ml), Glutamate antagonist;DL-AP4 sodium salt, glutamate antagonist | | CAS: | 1263093-79-3 | | MF: | C4H11NNaO5P | | MW: | 207.1 | | EINECS: | | | Product Categories: | Glutamate | | Mol File: | 1263093-79-3.mol |  |
| | DL-AP4 sodium salt Chemical Properties |
| storage temp. | Desiccate at RT | | form | Powder | | color | White | | Water Solubility | Soluble to 100 mM in water |
| | DL-AP4 sodium salt Usage And Synthesis |
| Uses | DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes[1][2]. | | storage | Room temperature (desiccate) | | References | [1] Thomsen C, et al., L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. Eur J Pharmacol. 1992 Nov 2;227(3):361-2. DOI:10.1016/0922-4106(92)90018-q
[2] Dolan RP, et al., Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. Vis Neurosci. 1994 Jan-Feb;11(1):23-32. DOI:10.1017/s095252380001107x |
| | DL-AP4 sodium salt Preparation Products And Raw materials |
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