| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:TolbutaMide-d9
CAS:1219794-57-6
Package:2.5Mg,25Mg
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| Company Name: |
Alta Scientific Co., Ltd.
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| Tel: |
022-6537-8550 15522853686 |
| Email: |
sales@altasci.com.cn |
| Products Intro: |
Product Name:Tolbutamide-d9
CAS:1219794-57-6
Purity:99% Package:10mg;100mg;1g
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| | Tolbutamide-d9 Basic information |
| | Tolbutamide-d9 Chemical Properties |
| Melting point | 108-111°C | | storage temp. | Refrigerator | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml | | form | A solid | | color | White to off-white |
| | Tolbutamide-d9 Usage And Synthesis |
| Description | Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes. | | Chemical Properties | White Solid | | Uses | Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine. | | References | [1] PETER PROKS. Sulfonylurea stimulation of insulin secretion.[J]. Diabetes, 2002, 51 Suppl 3: S368-76. DOI: 10.2337/diabetes.51.2007.s368
[2] NOBUYOSHI ISHIYAMA Jean C H Magalie A Ravier. Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets.[J]. American journal of physiology. Endocrinology and metabolism, 2006, 290 3: E540-9. DOI: 10.1152/ajpendo.00032.2005
[3] CLAUS RERUP Finn T. Streptozotocin- and alloxan-diabetes in mice[J]. European journal of pharmacology, 1969, 7 1: Pages 89-96. DOI: 10.1016/0014-2999(69)90169-1 |
| | Tolbutamide-d9 Preparation Products And Raw materials |
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