- Asaraldehyde
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- $39.00 / 1mL
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2026-02-01
- CAS:4460-86-0
- Min. Order:
- Purity: 99.76%
- Supply Ability: 10g
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| | 2,4,5-Trimethoxybenzaldehyde Basic information |
| | 2,4,5-Trimethoxybenzaldehyde Chemical Properties |
| Melting point | 112-114 °C (lit.) | | Boiling point | 140°C 4mm | | density | 1.2166 (rough estimate) | | refractive index | 1.5550 (estimate) | | Fp | 140°C/4mm subl. | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Fine Crystalline Powder | | color | White to light beige | | Water Solubility | <0.1 g/100 mL at 22 ºC | | Sensitive | Air Sensitive | | BRN | 1951403 | | InChI | 1S/C10H12O4/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-6H,1-3H3 | | InChIKey | IAJBQAYHSQIQRE-UHFFFAOYSA-N | | SMILES | [H]C(=O)c1cc(OC)c(OC)cc1OC | | LogP | 1.634 (est) | | CAS DataBase Reference | 4460-86-0(CAS DataBase Reference) | | NIST Chemistry Reference | Benzaldehyde, 2,4,5-trimethoxy-(4460-86-0) | | EPA Substance Registry System | 2,4,5-Trimethoxybenzaldehyde (4460-86-0) |
| | 2,4,5-Trimethoxybenzaldehyde Usage And Synthesis |
| Description | 2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a natural cyclooxygenase-2 (COX-2) activity inhibitor that is present in carrot seeds (Daucus carota L.) and can be synthesised using Indonesia Sweet Flag (Acorus calamus) as a raw material. 2,4,5-TMBA may serve as a synthetic intermediate component for various pharmaceuticals. In addition, 2,4,5-TMBA is also considered a candidate drug for oral non-steroidal anti-inflammatory drugs (NSAIDs)[1].
[1] LERRICK R I. Synthesis of Nonsteroidal Anti-Inflammatory Drug (NSAID) 2,4,5-Trimethoxybenzaldehyde from Indonesian Calamus oil and Its In Silico Pharmacokinetic Study[J]. Canadian Journal of Chemistry, 2022, 20 1. DOI:10.1139/cjc-2022-0121.
| | Chemical Properties | white to light beige fine crystalline powder | | Uses | fly attractant | | Uses | 2,4,5-Trimethoxybenzaldehyde is used in the synthesis of stilbene and hydrostibene derivatives as potential anticancer agents, inhibiting tubulin. Also used in the synthesis of HIV-RT inhibitors. | | Uses | A selective Cox-2 inhibitor. | | Definition | ChEBI: 2,4,5-trimethoxybenzaldehyde is a carbonyl compound. | | General Description | Beige powder. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2,4,5-Trimethoxybenzaldehyde is light sensitive. . | | Health Hazard | SYMPTOMS: Symptoms of exposure to related compounds are skin and gastrointestinal tract irritation, sensitization, blistering, nausea, vomiting, diarrhea, urinary tract irritation, initial excitement, convulsions and central nervous system depression. | | Fire Hazard | Flash point data for 2,4,5-Trimethoxybenzaldehyde are not available, but 2,4,5-Trimethoxybenzaldehyde is probably combustible. | | Biological Activity | 2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) is a bitter principle present in plant seeds, leaves, and roots. 2,4,5-TMBA exhibits anti-inflammatory, anti-adipogenic, and immunomodulatory activities. 2,4,5-TMBA has significant inhibitory effects on COX-2 activity. COX-2 not only plays a crucial role in inflammatory reactions, but also participates in the adipogenesis of 3T3-L1 cells via its derivative 15-deoxy-D12,14 prostaglandin (PG)J2 (15d-PGJ2). Studies indicate that 2,4,5-TMBA further inhibits lipogenesis and promotes lipolysis in 3T3-L1 adipocytes. This is closely associated with 2,4,5-TMBA's downregulation of proteins critical for adipogenesis, including CCAAT/enhancer-binding proteins (C/EBP) α, β, δ, peroxisome proliferator-activated receptor (PPAR)γ2, acyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and perilipin A in preadipocytes. In addition, carrot seed extracts rich in 2,4,5-TMBA exhibit immunomodulatory activity. |
| | 2,4,5-Trimethoxybenzaldehyde Preparation Products And Raw materials |
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