5-chloro-4-iodo-2-nitroaniline manufacturers
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| | 5-chloro-4-iodo-2-nitroaniline Basic information |
| | 5-chloro-4-iodo-2-nitroaniline Chemical Properties |
| Boiling point | 389.7±42.0 °C(Predicted) | | density | 2.169 | | storage temp. | 2-8°C(protect from light) | | pka | -2.43±0.25(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 5-chloro-4-iodo-2-nitroaniline Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 5-chloro-4-iodo-2-nitroaniline from 2-nitro-5-chloroaniline was as follows: first, a 50 mL round-bottomed flask was prepared and purged with nitrogen to maintain an inert atmosphere. To the flask was added 5-chloro-2-nitroaniline (10 g, 57.95 mmol, 1.00 eq.), acetic acid (100 mL) and N-iodosuccinimide (NIS, 13 g, 57.78 mmol, 1.00 eq.). The reaction mixture was stirred in an oil bath at 50 °C for 3 hours. Upon completion of the reaction, the mixture was poured into 300 mL of water and the resulting solid was collected by filtration. Subsequently, the solid was washed with 200 mL of saturated sodium bicarbonate solution and three times 200 mL of water. Ultimately, 17 g (88% yield) of 5-chloro-4-iodo-2-nitroaniline was obtained as a yellow solid. | | References | [1] Synlett, 2008, # 10, p. 1467 - 1470
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 24, p. 6811 - 6815
[3] MedChemComm, 2013, vol. 4, # 7, p. 1118 - 1123
[4] Patent: US2013/281392, 2013, A1. Location in patent: Paragraph 0148; 0150; 0151
[5] Patent: CN106496037, 2017, A. Location in patent: Paragraph 0026-0028 |
| | 5-chloro-4-iodo-2-nitroaniline Preparation Products And Raw materials |
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