Tertiapin Q manufacturers
- Tertiapin-Q
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- $147.00
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2026-07-15
- CAS:910044-56-3
- Purity: 98.09%
- Supply Ability: 10g
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| | Tertiapin Q Basic information |
| Product Name: | Tertiapin Q | | Synonyms: | Teriapin Q;L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide);Tertiapin-Q TFA | | CAS: | 910044-56-3 | | MF: | C106H175N35O24S4 | | MW: | 2452.01 | | EINECS: | | | Product Categories: | | | Mol File: | 910044-56-3.mol |  |
| | Tertiapin Q Chemical Properties |
| density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Soluble in water (2mg/ml) | | Sequence | Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridge: Cys3-Cys14, Cys5-Cys18) |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Tertiapin Q Usage And Synthesis |
| Uses | Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1). | | Biochem/physiol Actions | Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family. | | in vivo | Tertiapin-Q is a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker. After the cessation of rapid atrial pacing, the atrial effective refractory period (AERP) is unchanged during the experimental period in the rapid atrial pacing (RAP) rabbits (n=6). Bepridil (1 mg/kg, n=5 for each group), Amiodarone (10 mg/kg, n=5 for each group), Vernakalant (3 mg/kg, n=5 for each group), Ranolazine (10 mg/kg, n=6 for each group) or Tertiapin-Q (0.03 mg/kg, n=5 for each group) on the AERP in the control and RAP rabbits. Tertiapin-Q significantly prolongs the AERP at each pacing cycle length both in the control and RAP rabbits. The extents of prolonging effect of Tertiapin-Q on the AERP in the RAP rabbits are greater than those in the control animals[3]. | | storage | -20°C (desiccate) | | References | [1] Picton LD, et al. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Sci Rep. 2016 Oct 20;6:35749. DOI:10.1038/srep35749
[2] Günther T, et al. Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay. Mol Endocrinol. 2016 Apr;30(4):479-90. DOI:10.1210/me.2015-1241
[3] Chiba T, et al. Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. J Pharmacol Sci. 2016 Mar;130(3):170-6. DOI:10.1016/j.jphs.2016.02.007 |
| | Tertiapin Q Preparation Products And Raw materials |
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