(±)5,6-DHET lactone manufacturers
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| | (±)5,6-DHET lactone Basic information |
| Product Name: | (±)5,6-DHET lactone | | Synonyms: | (±)5,6-DHET lactone;(±)5(6)-DiHET lactone;(6S)-6-[(1R,3Z,6Z,9Z)-1-hydroxypentadeca-3,6,9-trienyl]oxan-2-one;2H-Pyran-2-one, tetrahydro-6-[(3Z,6Z,9Z)-1-hydroxy-3,6,9-pentadecatrien-1-yl]-;(±)5(6)-DiHET lactone;(+/-)5,6-DHET lactone;(±)5,6-DHET lactone, CAS 213126-92-2 | | CAS: | 213126-92-2 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 213126-92-2.mol |  |
| | (±)5,6-DHET lactone Chemical Properties |
| Boiling point | 483.4±40.0 °C(Predicted) | | density | 0.993±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | | pka | 13.89±0.20(Predicted) |
| | (±)5,6-DHET lactone Usage And Synthesis |
| Uses | 5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME. | | Definition | ChEBI: 5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic acid, 1,5-lactone is a long-chain fatty alcohol. | | References | [1] Oltman, et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998). |
| | (±)5,6-DHET lactone Preparation Products And Raw materials |
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