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| | 4-pentynoyl-Coenzyme A (trifluoroacetate salt) Basic information |
| | 4-pentynoyl-Coenzyme A (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 10 mg/ml |
| | 4-pentynoyl-Coenzyme A (trifluoroacetate salt) Usage And Synthesis |
| Description | 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins in vitro.1 As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.2WARNING This product is not for human or veterinary use. | | References | [1] YU-YING YANG Howard C H Janice M Ascano. Bioorthogonal Chemical Reporters for Monitoring Protein Acetylation[J]. Journal of the American Chemical Society, 2010, 132 11: 3640-3641. DOI: 10.1021/ja908871t
[2] HARTMUTH C KOLB K. B S. The growing impact of click chemistry on drug discovery[J]. Drug Discovery Today, 2003, 8 24: Pages 1128-1137. DOI: 10.1016/s1359-6446(03)02933-7 |
| | 4-pentynoyl-Coenzyme A (trifluoroacetate salt) Preparation Products And Raw materials |
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