PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody

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PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: Beijing Shengke Boyuan Biotechnology Co., Ltd.  
Tel: 010-62968438
Email: 978560024@qq.com
Company Name: Morning Student Science and Technology (Guangzhou) Co., Ltd.  
Tel: 020-36048871 13760856740
Email: chenxue_gz@163.com
Company Name: Boao Pike  
Tel: 010-57798038 15652371397
Email: lyn@biopike.com.cn
Company Name: Shanghai Chaoyan Biotechnology Co., Ltd.  
Tel: 021-50840550
Email: 471161314@qq.com
PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Basic information
Product Name:PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody
Synonyms:PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody
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PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Structure
PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Chemical Properties
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PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Usage And Synthesis
DescriptionCayman’s PHLPP1 Polyclonal Antibody detects the carboxy-terminal amino acids within the PDZ-binding domain of both the PHLPP1 α and β isoforms. PHLPP2 shares partial identity with the domains of PHLPP1 however it has a unique PDZ-binding domain sequence. Protein kinase B/Akt is critical in regulating cell growth and death. Activation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP1 and PHLPP2 dephosphorylate the hydrophobic motif of Akt and thus reduce Akt activity, resulting in a increase in the number of apoptotic cells.1 PHLPP1 levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP1 into mice reduced tumor size by nearly 70% compared with control animals. mRNA of PHLPP1 is ubiquitously expressed, with highest levels found in brain.1 Cayman’s PHLPP Polyclonal Antibody detects the enzyme at around 150 kDa (α isoform) and 200 kDa (β isoform) by western blot from various cell lines (THP-1) and tissues such as brain.WARNING This product is not for human or veterinary use.
PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody Preparation Products And Raw materials
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