| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PI 3-Kinase Inhibitor 2 B-0304
CAS:371943-05-4
Package:1Mg,5Mg
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:PI3-Kinase α Inhibitor 2
CAS:371943-05-4
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
|
| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:PI3-Kinase α Inhibitor 2 Exclusive
CAS:371943-05-4
Purity:98% Package:500μg;1mg;5mg
|
| Company Name: |
Shanghai Resuperpharmtech Co., Ltd.
|
| Tel: |
02150565560; 17321237488 |
| Email: |
kevin@resuperpharmtech.com |
| Products Intro: |
Product Name:PI3-Kinase α Inhibitor 2
CAS:371943-05-4
Purity:98% Package:1g;5g;10g
|
PI3-Kinase α Inhibitor 2 manufacturers
|
| | PI3-Kinase α Inhibitor 2 Basic information |
| Product Name: | PI3-Kinase α Inhibitor 2 | | Synonyms: | PI 3-Kinase Inhibitor 2 B-0304;Compound 15e;3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol;PI3-Kinase α Inhibitor 2;Compound 15e, 98.0+ % (HPLC);PI3-Kinase .alpha. Inhibitor 2;PI3-Kinase α Inhibitor 2 Exclusive;Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]- | | CAS: | 371943-05-4 | | MF: | C16H15N3O2S | | MW: | 313.37 | | EINECS: | | | Product Categories: | | | Mol File: | 371943-05-4.mol |  |
| | PI3-Kinase α Inhibitor 2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml | | form | White to off-white solid. | | color | White to off-white |
| | PI3-Kinase α Inhibitor 2 Usage And Synthesis |
| Description | PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM. | | Uses | PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1]. | | Definition | ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound. | | IC 50 | mTOR: 49 nM (IC50); PI3Kα: 41 nM (IC50) | | References | [1] Verheijen, Jeroen C et al. “Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.” Bioorganic & medicinal chemistry letters vol. 20,1 (2010): 375-9. DOI:10.1016/j.bmcl.2009.10.075 |
| | PI3-Kinase α Inhibitor 2 Preparation Products And Raw materials |
|