Prostaglandin F Synthase (human recombinant)

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Prostaglandin F Synthase (human recombinant) Basic information
Product Name:Prostaglandin F Synthase (human recombinant)
Synonyms:Prostaglandin F Synthase (human recombinant)
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Prostaglandin F Synthase (human recombinant) Structure
Prostaglandin F Synthase (human recombinant) Chemical Properties
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Prostaglandin F Synthase (human recombinant) Usage And Synthesis
DescriptionHuman prostaglandin F synthase (PGFS) is a ~37 kDa monomeric protein with high sequence similarity to aldo-keto reductase family members. It exhibits two related primary activities, catalyzing the isomerization of PGH2 to PGF2α (PGH2 9,11-endoperoxide reductase activity), as well as the formation of 11β-PGF2α from PGD2 (PGD2 11-ketoreductase activity) in the presence of NADPH. The enzyme also exhibits reductase activities toward carbonyl compounds such at nitroacetophenone, nitrobenzaldehyde, and 9,10-phenanthrene quinine (PQ). Cayman’s human recombinant PGFS has been expressed and purified from an E.coli overexpression system. Enzyme activity was determined by monitoring the change in absorbance at 340 nm using PGD2 as the substrate and NADPH as the cofactor (PGD2 11-ketoreductase activity).
References[1] YOSHIHIRO URADE  Osamu H  Kikuko Watanabe. Prostaglandin D, E, and F synthases[J]. Journal of lipid mediators and cell signalling, 1995, 12 2: Pages 257-273. DOI: 10.1016/0929-7855(95)00032-l
[2] T SUZUKI. cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthase.[J]. The Journal of Biological Chemistry, 1999, 274 1: 241-248. DOI: 10.1074/jbc.274.1.241
Prostaglandin F Synthase (human recombinant) Preparation Products And Raw materials
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