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| | 1,7-Naphthyridin-8-amine Basic information |
| Product Name: | 1,7-Naphthyridin-8-amine | | Synonyms: | 8-AMINO-1,7-NAPHTHYRIDINE;1,7phthyridin-8-ylamine;[1,7]Naphthyridin-8-ylaMine;1,7-Naphthyridin-8-amine, 8-Amino-1,7-diazanaphthalene;8-amino-1,7-naphthypridine;8-Amino-1,7-naphthyridine 95+%;1,7-Naphthyridin-8-amine | | CAS: | 17965-82-1 | | MF: | C8H7N3 | | MW: | 145.16 | | EINECS: | | | Product Categories: | | | Mol File: | 17965-82-1.mol |  |
| | 1,7-Naphthyridin-8-amine Chemical Properties |
| Melting point | 167-170°C | | Boiling point | 343.3±27.0 °C(Predicted) | | density | 1.292±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | solid | | pka | 5.54±0.30(Predicted) | | color | Yellow | | CAS DataBase Reference | 17965-82-1(CAS DataBase Reference) |
| | 1,7-Naphthyridin-8-amine Usage And Synthesis |
| Uses | 1,7-Naphthyridin-8-amine is a useful chemical in organic synthesis. | | Synthesis | a. A mixture of 2,3-diaminopyridine (5.0 g, 45.9 mmol), glycerol (21.1 g, 229 mmol), sodium 3-nitrobenzenesulfonate (20.6 g, 91.7 mmol), and sulfuric acid (20 mL) was added to water (30 mL), and the reaction was stirred for 16 hours at 135°C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into an ice-water mixture (150 g). After adjusting the pH of the mixture to neutral with base, it was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (2:1, v/v) as eluent to afford 1,7-naphthyridin-8-amine as a yellow solid (2.6 g, 39% yield). eSI MS: m/z 146.1 [M + H]+. | | References | [1] Patent: US2012/178748, 2012, A1. Location in patent: Page/Page column 47
[2] Patent: WO2017/14323, 2017, A1. Location in patent: Paragraph 0278 |
| | 1,7-Naphthyridin-8-amine Preparation Products And Raw materials |
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