2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
| 中文名称 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE |
|---|---|
| 中文同义词 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;化合物 T16352;化合物 NSC23925 |
| 英文名称 | 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride |
| 英文同义词 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride;NSC23925;NSC-23925;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride;NSC23925 HCl |
| CAS号 | 858474-14-3 |
| 分子式 | C22H25ClN2O2 |
| 分子量 | 384.9 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 858474-14-3.mol |
| 结构式 |  |
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | H2O：可溶5mg/mL（澄清溶液） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: 5mg/mL (clear solution) |
| InChI | 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H |
| InChIKey | WGWOQHWZXLGPNG-UHFFFAOYSA-N |
| SMILES | Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2 |
P-glycoprotein
NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor. SKOV-3 cells with long-term exposure of 1 μM NSC23925 show stable growth in culture medium. NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 µM. The IC 50 for NSC23925 is 8 µM in SKOV-3/SKOV-3 TR and 25 µM in OVCAR8/OVCAR8 TR cell lines, whereas the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3 TR or OVCAR8 TR to cytotoxic drugs is 0.5 µM to 1 µM.
Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925 | 858474-14-3 | 5mg | 1100元 |
| 2026/09/15 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE NSC23925 | 858474-14-3 | 10mg | 1900元 |