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Product Name:Alkyne-PEGn-NH2 2K, 5K, 10K, 20K
CAS:956348-61-1
Purity:98% Package:按需包装
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| | Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Basic information |
| | Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Chemical Properties |
| | Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Usage And Synthesis |
| Description | Propargyl-PEG12-amine is a heterobifunctional reagent that enables amide formation with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group is reactive with azide compounds via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The PEG units enhance the hydrophilicity of the molecule in aqueous media. | | Uses | Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Preparation Products And Raw materials |
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