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Cochemical Ltd. |
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029-86115547 17791676824 |
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sales@cochemical.com |
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| | 4-Bromo-2-fluoro-5-methylpyridine Basic information |
| | 4-Bromo-2-fluoro-5-methylpyridine Chemical Properties |
| Boiling point | 221.0±35.0 °C(Predicted) | | density | 1.592±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 1.05±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 4-Bromo-2-fluoro-5-methylpyridine Usage And Synthesis |
| Uses | 4-Bromo-2-fluoro-5-methylpyridine has properties and potential for diabetes treatment. | | Synthesis | General procedure for the synthesis of 4-bromo-2-fluoro-5-methylpyridine from 2-fluoro-3-bromo-5-methylpyridine: To a solution of 2-fluoro-3-bromo-5-methylpyridine (300 mg, 1.596 mmol) in tetrahydrofuran (THF, 10 mL) was added lithium diisopropylammonium (LDA, 2M, 0.8 mL) at -78°C and the reaction mixture was stirred at - 78 °C for 2 hours with stirring. Upon completion of the reaction, the reaction was quenched with 10 mL of water and extracted with ethyl acetate (EtOAc, 10 mL x 3). The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography (normal phase, silica gel, petroleum ether: ethyl acetate = 0-100%, UV 254 and UV 280 detection) to afford 4-bromo-2-fluoro-5-methylpyridine (130 mg, 43% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δppm: 2.37 (s, 3H), 7.19 (d 1H), 8.05 (s, 1H). | | References | [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6691 - 6703
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00181 |
| | 4-Bromo-2-fluoro-5-methylpyridine Preparation Products And Raw materials |
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